THE SECRETION ANTECEDENTS AND MITOCHONDRIA IN PATHOLOGIC THYROIDS

Abstract

That increased basal metabolism is associated with increased thyroid activity is well known and requires no comment here. It has, however, been observed that the pathologic picture in adenomas of the thyroid does not always correspond to the clinical state.¹ In exophthalmic goiter there is quite general agreement as to the pathologic changes present in the various stages of the disease.² The pathology of simple goiter and of fetal and simple adenomas is quite clear.³ It has long been known that certain nonexophthalmic goiters were accompanied by toxic symptoms. Plummer,⁴ in reviewing the cases at the Mayo Clinic, found that 23 per cent, of the nonexophthalmic goiters were toxic, and presented either one or the other of two definite clinical pictures: one type resembling exophthalmic goiter, and the other having a predominance of cardiac symptoms. Wilson⁵ reviewed the glands of the cases studied by Plummer,