Effects on abomasal function of Ostertagia circumcincta infections in sheep
- 6 April 1973
- journal article
- research article
- Published by Cambridge University Press (CUP) in Parasitology
- Vol. 66 (2), 241-257
- https://doi.org/10.1017/s0031182000045182
Abstract
Sheep in which abomasal fundic pouches had been made were infected with Ostertagia circumcincta (150000 larvae in one sheep, 100000 in three sheep). Subsequently studies were made on pouch secretion, food intake, plasma pepsinogens and abomasal pouch secretory responses when the sheep first ate. A functional abomasal lesion was apparent within 4 days of infection judged by the changes in plasma pepsinogen levels and the sodium concentrations of abomasal contents. Whereas the secretory activity of the abomasal fundic pouches (never exposed to parasites) was maintained or increased, the pH and sodium concentration of contents taken from the infected part of the abomasum were indicative of either a failure to secrete or of a permeability reabsorptive lesion. Ultrastructural studies demonstrated that parietal cells of the pouches had the appearance of cells subjected to strong secretory stimuli, but those of infected abomasa were similar to cells of gastric mucosa subjected to agents suppressing secretion. Factors which might operate, on the one hand, to stimulate secretion from separated fundic abomasal pouches, and on the other to inhibit or modify the secretory activity of the fundic mucosa of the infected abomasa, are discussed.Keywords
This publication has 23 references indexed in Scilit:
- Trichostrongylid infections of sheep in a winter rainfall region. I. Epizootiological studies in the Western District of Victoria, 1966-67Australian Journal of Agricultural Research, 1972
- Gastrin and its ActivitiesNature, 1970
- Abomasal secretory responses to teasing with food and feeding in the sheepThe Journal of Physiology, 1970
- The Development of Ostertagia circumcincta in LambsJournal of Helminthology, 1969
- CORRELATION OF THE FINE STRUCTURE OF THE GASTRIC PARIETAL CELL (DOG) WITH FUNCTIONAL ACTIVITY OF THE STOMACHThe Journal of cell biology, 1961
- Electron Microscope Observations on the Fine Structure of Parietal CellsThe Journal of cell biology, 1960
- Value of Plasma Pepsinogen EstimationBMJ, 1960
- The histotropic phase of the nematode parasite, Ostertagia circumcinta.Australian Journal of Agricultural Research, 1954
- Determination of chloride: A modification of the Volhard methodIndustrial & Engineering Chemistry Analytical Edition, 1935