Coumarin-Associated Hepatitis
- 1 August 1980
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Internal Medicine
- Vol. 140 (8), 1028-1029
- https://doi.org/10.1001/archinte.1980.00330190040016
Abstract
• We investigated two cases of recurrent jaundice, both involving repeated exposure to phenprocoumon and suggestive of coumarin-induced hepatitis. The first patient showed the histologic picture of cholestasis during the second bout of jaundice, the other that of chronic aggressive hepatitis. In both patients, the hepatitis appearance disappeared after termination of the first exposure to the coumarin drug, in the first case without additional drug therapy. In the second case, prednisone therapy was instituted when phenprocoumon administration was withdrawn. In both cases, hepatopathy recurred after reexposure to the drug. In one of these patients, and with his consent, a third bout of jaundice was provoked with phenprocoumon. (Arch Intern Med 140:1028-1029, 1980)Keywords
This publication has 2 references indexed in Scilit:
- Intrahepatic Jaundice due to Warfarin TherapyActa Medica Scandinavica, 1978
- PHENPROCOUMON-INDUCED JAUNDICEThe Lancet, 1976