Neurobehavioral effects of prenatal exposure to the organophosphate Diazinon in mice
- 1 December 1977
- journal article
- research article
- Published by Taylor & Francis in Journal of Toxicology and Environmental Health
- Vol. 3 (5-6), 989-1002
- https://doi.org/10.1080/15287397709529633
Abstract
Pregnant mice were given a daily dose of 0, 0.18, or 9.0 mg Diazinon per kilogram body weight throughout gestation. Mothers of all dose groups gave birth to viable, overtly normal offspring. However, pups born to mothers receiving the higher dose of the organophosphate grew significantly slower than controls and remained significantly smaller at 1 month of age. Offspring of mothers receiving the lower dose apparently were unaffected, but systematic behavioral testing revealed subtle deviations from normal developmental ontogeny as shown by significant delays in the appearance of the contact placing reflex and of sexual maturity (descent of testes or vaginal opening). Mature offspring of mothers exposed to either dose of the pesticide displayed impaired endurance and coordination on rod cling and inclined plane tests of neuromuscular function. Offspring from the 9.0 mg/kg group, in addition, had slower running speeds in a Lashley III maze and less endurance in a swimming test. Brains obtained after sacrifice at 101 days of age revealed neuropathology in the forebrains of offspring born of mothers exposed to the higher dose. Despite functional impairments in offspring from the lower dose group, no corresponding brain pathology was observed by examination under the light microscope.This publication has 17 references indexed in Scilit:
- Response model analysis for cross-fostering studies: Prenatal versus postnatal effects on offspring exposed to methylmercury dicyandiamideToxicology and Applied Pharmacology, 1977
- Ultrastructural study of the latent effects of methyl mercury on the nervous system after prenatal exposureEnvironmental Research, 1977
- Pesticide residues and field workersEnvironmental Science & Technology, 1975
- Teratologic studies of carbaryl, diazinon, norea, disulfiram, and thiram in small laboratory animalsToxicology and Applied Pharmacology, 1969
- Effect of DDT or Parathion on Open-Field Behavior of Offspring from DDT- or Parathion-Treated MothersPsychological Reports, 1968
- Effect of DDT or Parathion on condition avoidance response of offspring from DDT or Parathion treated mothersPsychopharmacology, 1968
- Effect of DDT or Parathion on Audiogenic Seizures of Offspring from Ddt- or Parathion-Treated MothersPsychological Reports, 1967
- THE EFFECT OF ACUTE AND CHRONIC TREATMENT WITH DIISOPROPYL FLUOROPHOSPHATE ON CHOLINESTERASE ACTIVITIES OF SOME TISSUES OF THE RATImmunology & Cell Biology, 1966
- The Effect of Audiogenic Seizures on General Activity of the White RatPublished by JSTOR ,1941
- Emotional behavior in the rat. I. Defecation and urination as measures of individual differences in emotionality.Journal of Comparative Psychology, 1934