Histochemical and metabolic characteristics of human skeletal muscle in relation to age
- 1 January 1986
- journal article
- research article
- Published by Wiley in Acta Physiologica Scandinavica
- Vol. 126 (1), 107-114
- https://doi.org/10.1111/j.1748-1716.1986.tb07793.x
Abstract
Muscle fibre composition, fibre areas and enzyme activities were determined in muscle biopsy samples (m. vastus lateralis) from both legs of 34 clinically healthy men and 31 clinically healthy women (aged 20-70 years). No significant difference was found in any of the three variables between the right and left leg. In the whole material the mean percentage of type I fibres was significantly higher in men, whereas that of type IIA fibres was significantly higher in women (men 58% I, 27% IIA, 13% IIB, women 51% I, 32% IIA, 15% IIB). The areas of all fibre types were significantly larger in men than in women. When the subjects were divided into age groups of 20, 30, 40, 50, 60 and 70 years, respectively, the fibre composition was found to be similar at different ages in both men and women, but changes in fibre areas were observed. The 70-year-old men and women showed significantly reduced areas of both type I and II fibres compared with the 60-year-olds. Only minor changes were seen in enzyme activities in relation to age. Men of the youngest age group had significantly higher levels of citrate synthase activity than those of the older age groups. Similar findings were seen for women except for the 60-year-olds, who had as high activity levels of citrate synthase as the 20-year-olds.Keywords
This publication has 29 references indexed in Scilit:
- How to calculate human muscle fibre areas in biopsy samples-methodological considerationsActa Physiologica Scandinavica, 1984
- Fibre types, enzyme activities and substrate utilisation in skeletal muscles of horses competing in endurance ridesEquine Veterinary Journal, 1984
- Is there a change in relative muscle fibre composition with age?Clinical Physiology and Functional Imaging, 1984
- Distribution of different fibre types in human skeletal muscles 2. A study of cross‐sections of whole m. vastus lateralisActa Physiologica Scandinavica, 1983
- The needle biopsy technique for fibre type determination in human skeletal muscle–a methodological studyActa Physiologica Scandinavica, 1982
- Intramuscular variation of fiber types in the brachial biceps and the lateral vastus muscles of elderly men: How representative is a small biopsy sample?The Anatomical Record, 1982
- Morphology and enzymatic capacity in arm and leg muscles in 78–81 year old men and womenActa Physiologica Scandinavica, 1982
- Muscle morphology, enzyme activity and muscle strength in elderly men and womenClinical Physiology and Functional Imaging, 1981
- Muscle Adaptation to Extreme Endurance Training in ManActa Physiologica Scandinavica, 1977
- Metabolic Characteristics of Fibre Types in Human Skeletal MuscleActa Physiologica Scandinavica, 1975