Three years of clinical experience with 79 cadaver renal transplantations on 69 patients at the Cleveland Clinic Hospital is reported with a minimal follow-up study of 12 months after transplantation. Twenty-four of the 69 patients have a functioning allograft and eight of them are now living for two years or more after transplantation. Oliguria develops after cadaver renal transplantation and may last for periods up to 25 days postoperatively. The cause of the oliguria is usually acute tubular necrosis but when it is prolonged other possible causes must be considered. A warm ischemic time greater than 60 minutes markedly reduced the chances for a successful functioning renal allograft obtained from a cadaver donor. Postoperative problems and the cause of allograft failure are discussed. Experience to date indicates that renal transplantation using cadaver donors for the allograft is sufficiently successful to encourage further work in this field.