HL-A Frequencies in Down's syndrome
- 1 March 1975
- journal article
- research article
- Published by Springer Nature in Humangenetik
- Vol. 27 (1), 45-48
- https://doi.org/10.1007/bf00283502
Abstract
Summary HL-A antigen frequencies were examined in 76 Down's syndrome individuals and 733 normal Caucasians. 10 antigens of the first locus and 15 antigens of the second locus were defined, using a microlymphocytotoxicity technique. No significant differences were observed between the normal and Down's syndrome samples, in contrast to a previous report (Boxer and Yokoyama, 1972) of decreased HL-A antigen frequencies in Down's syndrome individuals. Our results therefore suggest that there is no relationship between trisomy 21-associated immune aberrations and altered HL-A antigen frequencies.Keywords
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