Bud formation by the yeast Saccharomyces cerevisiae is directly dependent on "start".
Open Access
- 1 February 1984
- journal article
- research article
- Published by Rockefeller University Press in The Journal of cell biology
- Vol. 98 (2), 678-684
- https://doi.org/10.1083/jcb.98.2.678
Abstract
Cells of the yeast Saccharomyces cerevisiae, which bear a cdc4 gene mutation, arrest early in the cell cycle but continue to produce buds in a periodic fashion. We show here that this periodic bud formation by cells already arrested at the CDC4 step is inhibited if the cell cycle regulatory step "start" is also specifically blocked by mutation or by the presence of the yeast mating pheromone alpha-factor. Thus, the characteristic periodic bud formation by cdc4 mutant cells requires the continued ability to perform start. This finding raises questions concerning the nature of start; these issues are discussed.This publication has 20 references indexed in Scilit:
- Molecular analysis of a cell lineageNature, 1983
- Periodic transcription of yeast histone genesCell, 1982
- A bifunctional gene product involved in two phases of the yeast cell cycleNature, 1982
- Cell cycle phase expansion in nitrogen-limited cultures of Saccharomyces cerevisiae.The Journal of cell biology, 1980
- The use of conditional lethal cell cycle mutants of temporal and functional sequence mapping of cell cycle eventsJournal of Cellular Physiology, 1978
- Unequal division in Saccharomyces cerevisiae and its implications for the control of cell division.The Journal of cell biology, 1977
- Coordination of growth with cell division in the yeastExperimental Cell Research, 1977
- Saccharomyces cerevisiae cell cycle.1974
- Sequential gene function in the initiation of Saccharomyces cerevisiae DNA synthesisJournal of Molecular Biology, 1974
- Genetic control of the cell division cycle in yeastJournal of Molecular Biology, 1971