Spontaneous Hemorrhage with Anticoagulants

Abstract

When dicumarolized animals are subjected to various types of stress, a high mortality from spontaneous internal hemorrhage occurs. This phenomenon is observed with various combinations of the treatments—Dicumarol, phenylindanedione, heparin, frostbite, insulin convulsions, hypertonic saline intraperitoneally, adrenalectomy, adrenocorticotropic hormone, corticosteroids, histamine, adrenalin, salicylates, P³², reserpine. Hemostasis depends on blood coagulation, platelets, and vascular integrity. Experimental results demonstrate that spontaneous hemorrhage results when any two of these mechanisms are deranged simultaneously. Hormonal and neural factors affect the blood vessels and in this way determine spontaneous hemorrhage with anticoagulants. Spontaneous hemorrhage has a multiple causation.