Platelet Function in Patients with Diabetes Mellitus: From a Theoretical to a Practical Perspective
Open Access
- 21 August 2011
- journal article
- review article
- Published by Hindawi Limited in International Journal of Endocrinology
- Vol. 2011, 1-14
- https://doi.org/10.1155/2011/742719
Abstract
Patients with diabetes mellitus have an increased prevalence of vascular disease. Pathologic thrombosis associated with atherosclerotic plaque rupture is a major cause of morbidity and mortality. Platelets are intimately involved in the initiation and propagation of thrombosis. Evidence suggests that platelets from patients with type 2 diabetes have increased reactivity and baseline activation compared to healthy controls. We review the pathophysiology of platelet hyperreactivity in DM patients and its implications in clinical practice, with particular focus on acute coronary syndromes, percutaneous coronary intervention, and novel antiplatelet agents.Keywords
This publication has 116 references indexed in Scilit:
- Effects of Aspirin Responsiveness and Platelet Reactivity on Early Vein Graft Thrombosis After Coronary Artery Bypass Graft SurgeryJournal of the American College of Cardiology, 2011
- Aspirin for primary prevention of cardiovascular disease in diabetes mellitusNature Reviews Endocrinology, 2010
- Double-blind, placebo-controlled Phase II studies of the protease-activated receptor 1 antagonist E5555 (atopaxar) in Japanese patients with acute coronary syndrome or high-risk coronary artery diseaseEuropean Heart Journal, 2010
- Ticagrelor vs. clopidogrel in patients with acute coronary syndromes and diabetes: a substudy from the PLATelet inhibition and patient Outcomes (PLATO) trialEuropean Heart Journal, 2010
- Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON–TIMI 38 trial: a pharmacogenetic analysisThe Lancet, 2010
- Hyperglycemia Is Associated With Enhanced Thrombin Formation, Platelet Activation, and Fibrin Clot Resistance to Lysis in Patients With Acute Coronary SyndromeDiabetes Care, 2008
- Diabetes and vessel wall remodelling: from mechanistic insights to regenerative therapiesCardiovascular Research, 2008
- Aspirin “resistance” and risk of cardiovascular morbidity: systematic review and meta-analysisBMJ, 2008
- Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patientsBMJ, 2002
- Obesity and insulin resistanceJCI Insight, 2000