Synthesis of optically Active 5-(3-tert-Butylamino-2-hydroxypropoxy)-3, 4-dihydrocarbostyril Hydrochloride and Their β-Adrenergic Blocking Activities

Abstract

Optical isomers of 5-(3-tert-butylamino-2-hydroxypropoxy)-3,4-dihydrocarbostyril hydrochloride were synthesized and their anti-isoproterenol activity was examined in anesthetized dog. (S)(-)-isomers was about 20 times more active than (R)(+)-isomer.