Evidence for T cell receptor‐HLA class II molecule interaction in the response to superantigenic bacterial toxins
- 1 May 1991
- journal article
- Published by Wiley in European Journal of Immunology
- Vol. 21 (5), 1331-1333
- https://doi.org/10.1002/eji.1830210537
Abstract
The staphylococcal enterotoxins and related microbial T cell mitogens stimulate T cells by cross‐linking variable parts of the T cell receptor (TcR) with MHC class II molecules on accessory or target cells. In this report we describe that a given combination of T cell, accessory cell (AC) and toxin can be non‐stimulatory. However, the same T cell can respond to the same toxin on another AC and the same AC can present the same toxin to another T cell. This indicates that in the complex formed between TcR, toxin and class II molecule an interaction between TcR and class II molecule takes place.Keywords
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