Long-Term Efficacy of Captopril (SQ 14,225) In 2-Kidney Renal Hypertensive Rats
- 31 December 1978
- journal article
- research article
- Published by Taylor & Francis in Clinical and Experimental Hypertension
- Vol. 1 (4), 505-519
- https://doi.org/10.3109/10641967909068621
Abstract
The effects of daily captopril therapy (30 mg/kg p.o.) given for one year on systolic blood pressure, heart rate and survival of 2-kidney renal hypertensive rats (2K-RHR) were examined. Captopril caused significant and sustained reductions in systolic blood pressure of 2K-RHR throughout the 1-year period with no important changes in heart rate. Simultaneous administration of the diuretic hydrochlorothiazide (HCTZ) enhanced the antihypertensive effect of captopril but did not normalize blood pressure, this despite no effect on blood pressure by HCTZ given alone. On the other hand, co-administration of guanethidine with captopril normalized blood pressure. Survival rates of 2K-RHR were highest in the rats receiving captopril plus HCTZ, next highest in rats receiving captopril alone and lowest in rats receiving water or HCTZ. The results demonstrate the long-term efficacy of captopril and suggest a sympathetic component in the maintenance of chronic 2-kidney renal hypertension.This publication has 15 references indexed in Scilit:
- Antihypertensive Effect of the Oral Angiotensin Converting-Enzyme Inhibitor SQ 14225 in ManNew England Journal of Medicine, 1978
- Design of Specific Inhibitors of Angiotensin-Converting Enzyme: New Class of Orally Active Antihypertensive AgentsScience, 1977
- Role of adrenergic innervation in experimental renal hypertensionLife Sciences, 1977
- Development and maintenance of renal hypertension in normal and guanethidine sympathectomized rats.Circulation Research, 1975
- Alteration of the Course of Hypertension in the Spontaneously Hypertensive RatCirculation Research, 1972
- Hypertension: Definitions, natural histories and consequencesAmerican Journal Of Medicine, 1972
- Effect of Sodium Restriction on Renal Hypertension and on Renin Activity in the RatCirculation Research, 1970
- An assessment of the role of the sympathetic nervous system in experimental hypertension using normal and immunosympathectomized ratsBritish Journal of Pharmacology, 1970
- Does the adrenal medulla contribute to the maintenance of experimental hypertension?European Journal of Pharmacology, 1970
- Relation of Plasma Renin to Sodium Balance and Arterial Pressure in Experimental Renal HypertensionCirculation Research, 1966