Solution conformation of sialosylcerebroside (GM4) and its NeuAc(α2→3)Galβ sugar component
- 3 March 1989
- journal article
- research article
- Published by Wiley in European Journal of Biochemistry
- Vol. 180 (2), 337-342
- https://doi.org/10.1111/j.1432-1033.1989.tb14653.x
Abstract
The solution conformations of GM4 ganglioside [NeuAc(.alpha.2 .fwdarw. 3)Gal(.beta.1 .fwdarw. 1)Cer] in (2H3C)2SO and its component disaccharide in 2H2O were investigated with the aid of 1H-nuclear magnetic resonance spectroscopy (nuclear Overhauser effect, analysis of coupling constants) and by energy-minimum calculations. The existence of three low-energy conformers obtained by theoretical caculations was supported by experimental findings in the case of GM4, whereas the disaccharide appears to exist as a mixture of two conformers.This publication has 28 references indexed in Scilit:
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