High resolution two-dimensional electrophoresis of human plasma proteins.
- 1 December 1977
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 74 (12), 5421-5425
- https://doi.org/10.1073/pnas.74.12.5421
Abstract
The 2-dimensional electrophoretic technique of O''Farrell was adapted to the analysis of human plasma proteins, and 30 polypeptides were identified in the pattern produced. Genetic variants involving charge (isoelectric point) or size (MW in the presence of sodium dodecyl sulfate) changes should be routinely detectable in at least 20 proteins at once, facilitating studies of human mutation rates.Keywords
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