Familial fragility on chromosome 16 (Fra 16q22) enhanced by both interferon and distamycin A
- 1 June 1983
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 63 (4), 341-344
- https://doi.org/10.1007/bf00274759
Abstract
A family with a “fragile site” at 16q22, inducible by both interferon and Distamycin A, is reported. Immunological problems were found in the family. In a sibship of ten, eight children had died in infancy. Our study led to the conclusions that interferon and Distamycin A induce fragility at the same site, which has the same characteristics as the spontaneous fragile site; that a viral hypothesis for this fragility may be supported; and that immunoincompetence of one kind or another must be considered in families presenting a fragile site at 16q22.This publication has 23 references indexed in Scilit:
- Suppressive effect of interferon on the occurrence of chromosome aberrationsHereditas, 2009
- The effect of in vitro distamycin A exposure on metaphase chromosome structureHereditas, 2008
- Human leukocyte interferon does not induce sister-chromatid exchanges in human blood lymphocytesMutation Research Letters, 1982
- HUMAN FIBROBLAST INTERFERON DOES NOT INDUCE CHROMOSOMAL ABNORMALITIESThe Lancet, 1981
- The fragile site at 16q22, distamycin A, and the normal pachytene structure of chromosome 16: some possible interrelationshipsCytogenetic and Genome Research, 1981
- EPSTEIN-BARR-VIRUS-INDUCED LYMPHOPROLIFERATIVE DISORDER CONVERTING TO FATAL BURKITT-LIKE LYMPHOMA IN A BOY WITH INTERFERON- INDUCIBLE CHROMOSOMAL DEFECTThe Lancet, 1980
- Genetic mechanisms in cancer predisposition.Report of a cancer familyCancer, 1979
- Induction of Infectious Virus DNA and Virus Particles by Mitomycin C in SV40-Transformed Mouse CellsJournal of General Virology, 1978
- Effects of the antibiotic netropsin on mouse ascites tumour chromosomes in vitroCellular and Molecular Life Sciences, 1977
- Decondensation of constitutive heterochromatin in L cell chromosomes by a benzimidazole compound (“33258 Hoechst”)Experimental Cell Research, 1973