Comparison of Two Serologically Distinct Ribonucleic Acid Bacteriophages I. Properties of the Viral Particles

Abstract
Two ribo-nucleic acid (RNA) coliphages, MS-2 and Q[beta], have been characterized physically and serologically. MS-2 has an S20, w value of 79, a molecular weight of 3.6 x 106, a density of 1.422, and pH 3.9 as its isoelectric point. Q[beta] has an S20, w of 84, a molecular weight of 4.2 x 106, a density of 1.439, and an isoelectric point at pH 5.3. One host (Escherichia coli A-19) permits a distinction between the two on the basis of a marked difference in plaque size. They are distinct immunochemically, no serological cross-reaction being detectable.

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