Surface Modification of T-Lymphocytes Observed during Rosetting
- 21 June 1974
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 184 (4143), 1300-1301
- https://doi.org/10.1126/science.184.4143.1300
Abstract
Scanning electron microscopy has been used to characterize alterations of lymphocyte surface topology that occur on contact with erythrocytes during the rosetting reaction. Molt-4 cells, a line of leukemic human lymphocytes, defined as T-cells through their ability to form rosettes with sheep erythrocytes, were used for this. Unreacted Molt-4 cells exhibit surfaces that are virtually smooth and carry few microvilli. In contrast, Molt-4 cells in rosettes display a time-dependent modification of surface topology, characterized by the emergence of numerous, long microvilli, particularly in areas of red cell contact.Keywords
This publication has 2 references indexed in Scilit:
- Scanning Electron Microscopy of Human T-Cell and B-Cell RosettesNew England Journal of Medicine, 1973
- IDENTIFICATION OF HUMAN B AND T LYMPHOCYTES BY SCANNING ELECTRON MICROSCOPYThe Journal of Experimental Medicine, 1973