Direct adrenocortical stimulatory effect of serotonin
- 30 November 1961
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 201 (6), 1065-1067
- https://doi.org/10.1152/ajplegacy.1961.201.6.1065
Abstract
By means of direct arterial perfusion of the adrenal glands of the hypophysectomized dog, it was found that serotonin stimulated the secretion of hydrocortisone to a degree comparable to that seen during ACTH stimulation. Neither 5-hydroxytryptophan nor reserpine had this stimulatory effect. Physiologic mechanisms to explain the serotonin effect are discussed.Keywords
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