Clinical testing of new antimalarial compounds.
- 1 January 1974
- journal article
- clinical trial
- Vol. 50, 203-12
Abstract
More than 200 000 chemical compounds have been screened for antimalarial activity over the past 10 years by the US Army Antimalarial Drug Development Program. By means of extensive animal testing, 26 of these compounds were selected for clinical study in human subjects volunteering for such trials. Of these, 7 have received complete clinical trials and are in various stages of field evaluation, 4 are currently undergoing clinical trial, and 2 are still awaiting testing in volunteer subjects. Thus far, 2 compounds (WR 33 063 and WR 30 090) have demonstrated greater activity against drug-resistant Plasmodium falciparum than any other known drug. Several other compounds presently being tested in human subjects are even more potent.This publication has 15 references indexed in Scilit:
- The Chemoprophylactic Use of Diformyl Diaminodiphenyl Sulfone (DFD) in Falciparum MalariaThe American Journal of Tropical Medicine and Hygiene, 1972
- Diformyl diaminodiphenyl sufone (DFD) as an antimalarial in man.1970
- Agranulocytosis Due to DapsoneAnnals of Internal Medicine, 1970
- Malaria chemoprophylaxis with 4,4' diaminodiphenylsulfone (DDS). I. Field trial with comparison among companies of one division.1969
- Malaria chemoprophylaxis with 4,4' diaminodiphenylsulfone (DDS). II. Field trial with comparison between two divisions.1969
- The Army Malaria Research ProgramAnnals of Internal Medicine, 1969
- Trimethoprim in Therapy of Acute Attacks of MalariaThe Journal of Clinical Pharmacology and The Journal of New Drugs, 1967
- Chloroquine-Resistant Plasmodium falciparum: Protective and Hemolytic Effects of 4,4′-Diaminodiphenylsulfone (DDS) Administered Daily Together with Weekly Chloroquine and PrimaquineMilitary Medicine, 1967
- The effects of diaphenylsulfone (DDS) against chloroquine-resistant Plasmodium falciparum.1966
- The haemolytic effects of diaphenylsulfone (DDS) in normal subjects and in those with glucose-6-phosphate-dehydrogenase deficiency.1966