Ring-Opening Reactions of Epoxides with Trimethylsilyl Cyanide Catalyzed by Titanium Alkoxide-Schiff Base Complexes

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Abstract
The addition of Schiff base 4 [6-tert-butyl-2-(2-hydroxyethyliminomethyl)phenol] possessing a tert-butyl group accelerated the rate of ring-opening reactions of epoxides with trimethylsilyl cyanide catalyzed by titanium(IV) isopropoxide to afford the corresponding ß-trimethylsiloxy nitriles in a stereo- and regioselective manner.