Secretory IgA: immune defence pattern in ankylosing spondylitis and klebsiella.
Open Access
- 1 December 1981
- journal article
- research article
- Published by BMJ in Annals Of The Rheumatic Diseases
- Vol. 40 (6), 600-604
- https://doi.org/10.1136/ard.40.6.600
Abstract
Saliva secretory IgA (sIgA), secretory component (SC); serum immunoglobulins (IgG, IgA, IgM), complement (C3, C4), C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) were performed in 32 patients with ankylosing spondylitis and 29 normal controls. They were investigated for carriage in the faeces of Klebsiella spp. on 3 occasions over the previous months. Throat swabs and urine were cultured at the same time as immunological estimations were done. 24-hour urine sIgA specimens were studied in 13 patients and 12 normal controls. Significantly raised mean values of saliva sIgA and serum IgG, IgA, C3, and C4 were found in patients with raised values of serum ESR and CRP levels when correlated with controls. Raised values of sIgA in saliva, which is an important factor of the local immune defence mechanism of mucosal surfaces, suggests the presence of an antigenic stimulus from the gastrointestinal system in ankylosing spondylitis during activity of disease.This publication has 20 references indexed in Scilit:
- C-reactive protein, ESR, and klebsiella in ankylosing spondylitis.Annals Of The Rheumatic Diseases, 1980
- An investigation into the incidence and sources of klebsiella infections in hospital patientsEpidemiology and Infection, 1979
- Sequential studies in ankylosing spondylitis. Association of Klebsiella pneumoniae with active disease.Annals Of The Rheumatic Diseases, 1978
- ANKYLOSING SPONDYLITIS: KLEBSIELLA AND HL-A B27Rheumatology, 1977
- ANKYLOSING SPONDYLITIS AND HL-A 27The Lancet, 1973
- Secretory γA in normal urineJCI Insight, 1968
- Immunochemical quantitation of antigens by single radial immunodiffusionImmunochemistry, 1965
- Bone and joint changes in paraplegic men.Annals Of The Rheumatic Diseases, 1965
- UVEITIS AND UROGENITAL DISEASE IN THE MALEBritish Journal of Ophthalmology, 1961
- Prostatitis and Ankylosing SpondylitisBMJ, 1958