Antagonlstic Effects on the Sinus Node of Acetylstrophanthidin and Adrenergic Stimulation

Abstract

Acetylstrophanthidin perfused directly into the sinus node artery of the dog decreases the response of the sinus node to adrenergic stimulation. When sinus arrest followed per-fusion of high concentrations of glycosides, either sympathetic stimulation or intranodal epinephrine transiently restored sinus rhythm.