Excision repair of benzo[a]pyrene-deoxyguanosine adducts in baby hamster kidney 21/C13 cells and in secondary mouse embryo fibroblasts C57BL/6J.
- 1 March 1977
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 74 (3), 979-983
- https://doi.org/10.1073/pnas.74.3.979
Abstract
The formation and excision of benzo[a]pyrene-deoxyguanosine adducts in metabolizing baby hamster kidney cells (21/C13) and secondary mouse embryo fibroblasts (C57BL/6J) was investigated. Both diastereomeric adducts, N2-(10-(7beta,8alpha,9alpha-trihydroxy-7, 8, 9, 10 tetrahydrobenzo[a]-7,8,9,10-tetrahydrobenzo[a]pyrene)yl)deoxyguanosine, were detected in both cell lines and both cell lines were capable of excising these lesions, albeit with low efficiency.Keywords
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