A CONVENIENT METHOD FOR THE SYNTHESIS OF CARBOXAMIDES AND PEPTIDES BY THE USE OF TETRABUTYLAMMONIUM SALTS
- 5 March 1981
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 10 (3), 285-288
- https://doi.org/10.1246/cl.1981.285
Abstract
Various carboxamides and peptides are prepared in good yields by treatment of free acids and amines in H2O-dichloromethane or aqueous THF with bis(o-nitrophenyl) phenylphosphonate in the presence of tetrabutylammonium hydrogen sulfate or bromide. Carboxylic esters are also successfully converted to amides via carboxylate salts in one-pot.Keywords
This publication has 4 references indexed in Scilit:
- Reaction of carboxylate salts with cyclic phosphoramidates: amide bond formation by prior amine captureTetrahedron Letters, 1980
- Selective Reductions. V. The Partial Reduction of Tertiary Amides by Lithium Di- and Triethoxyaluminohydrides-A New Aldehyde Synthesis via the DimethylamidesJournal of the American Chemical Society, 1964
- Peptide Syntheses Via Amino Acid Active Esters1Journal of the American Chemical Society, 1959
- The Use of Diester Chlorophosphites in Peptide Syntheses. Mixed Anhydrides1Journal of the American Chemical Society, 1952