Correlation of Initial Thiothixene Serum Levels and Clinical Response
- 1 March 1983
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of General Psychiatry
- Vol. 40 (3), 301-304
- https://doi.org/10.1001/archpsyc.1983.01790030071009
Abstract
• A series of three experiments addressed major problems concerning the use of serum levels as predictors of clinical response to thiothixene (Navane) hydrochloride in schizophrenia: correlation of initial test doses with clinical response; comparison of fluorescence spectrophotometry with gas chromatography in relation to clinical response; and comparison of serum levels with RBC levels in relation to clinical response. All assays correlated (nearr=.5) with Brief Psychiatric Rating Scale improvement during hospitalization, except RBC levels seemed to have superior correlations (.64) in patients with lower serum levels. These correlations are similar to those obtained with steady state levels. The different methods of determining thiothixene concentrations were highly intercorrelated as well. Thus, single-dose serum levels give important clinical correlations regardless of which assay is used for thiothixene determination.Keywords
This publication has 7 references indexed in Scilit:
- Correlation of thiothixene serum levels and agePsychopharmacology, 1981
- Predicting outcome of antipsychotic drug treatment from early responseAmerican Journal of Psychiatry, 1980
- Plasma Levels of Chlorpromazine in SchizophreniaArchives of General Psychiatry, 1978
- Controlled trial of penfluridol and thiothixene in the maintenance treatment of chronic schizophrenic syndromesActa Psychiatrica Scandinavica, 1976
- High‐Pressure Liquid Chromatographic Determination of Thiothixene in Pharmaceutical FormulationsJournal of Pharmaceutical Sciences, 1976
- Determination of Thioxanthenes in Plasma at Therapeutic ConcentrationsActa Pharmacologica et Toxicologica, 1971
- Metabolism of ThiothixeneJournal of Pharmaceutical Sciences, 1968