Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease
- 29 July 2005
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 102 (32), 11272-11277
- https://doi.org/10.1073/pnas.0504783102
Abstract
B cell homeostasis is maintained by a balance between the continual generation of new cells and their elimination. Here we show proapoptotic BCL-2 family members BAX and BAK are essential for regulating the number of B cells at both immature and mature developmental stages. BAX and BAK are critical mediators of B cell death induced by multiple stimuli. In addition, BAX- and BAK-deficient B cells display defective cell cycle progression to B cell receptor crosslinking and lipopolysaccharide, but not to CpG–DNA. Furthermore, inducible deletion of Bax and Bak in adult mice results in the development of severe autoimmune disease.Keywords
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