Effect of Hydroxyethyl Starch on Platelet Function Following Granulocyte Collection Using the Continuous Flow Cell Separator

Abstract

Hydroxyethyl starch (HES) was used as sedimenting agent in the course of granulocyte collection on 17 normal donors using the continuous flow cell separator (CFCS). No clinical bleeding was noted in any of the donors. In spite of a 21% mean reduction in postcollection platelet count, all donors had platelet counts within normal limits precollection and postcollection. Postcollection platelet adhesiveness increased in 5 donors, remained the same in 1 donor and declined in 10 donors. Except in 1 donor, there was no change in previously normal platelet aggregation to ADP or collagen. In the dose used, 500 ml, the infusion of 6% hydroxyethyl starch as an adjunct to granulocyte separation using the continuous flow cell separator does not appear to adversely affect platelet number and function.