METABOLIC PATTERNS DURING PHYSIOLOGIC SLEEP: I. BLOOD GLUCOSE REGULATION DURING SLEEP IN NORMAL AND DIABETIC SUBJECTS*

Abstract

A technique of blood sampling was used which allowed continued sleep by the subject. True glucose rather than total reducing substances were measured. Normal subjects showed essentially constant blood glucose concentrations during sleep. Patients with diabetes mellitus showed marked variations in blood glucose concentrations during sleep. Such variations have important therapeutic implications for the management of diabetic patients.