Numerical Integration Simulation Programs for the Microcomputer
- 1 January 1980
- journal article
- research article
- Published by Wolters Kluwer Health in Therapeutic Drug Monitoring
- Vol. 2 (3), 243-248
- https://doi.org/10.1097/00007691-198007000-00007
Abstract
Programs for use with the Apple II Plus microcomputer that generate graphic simulations of various linear and Michaelis-Menten pharmacokinetic models are described. The programs numerically integrate sets of differential equations for appropriate pharmacokinetic models. Multiple oral (or i.m.), i.v. bolus or infusion doses (continuous or discontinuous) may be administered in any combination. Doses and pharmacokinetic parameters may be changed at the end of each simulated dosing interval. The programs can be easily modified by users familiar with the BASIC programming language and offer an economical approach to human pharmacokinetic simulation.This publication has 1 reference indexed in Scilit:
- Kinetic model for gentamicin dosing with the use of individual patient parametersClinical Pharmacology & Therapeutics, 1977