Serological Evidence of Hepatitis B Infection in Patients with Chronic Liver Diseases: Radioimmunoassay of HBSAg and anti-HBS
- 1 July 1977
- journal article
- research article
- Published by Taylor & Francis in Scandinavian Journal of Gastroenterology
- Vol. 12 (5), 615-619
- https://doi.org/10.3109/00365527709181343
Abstract
The prevalence of hepatitis B surface antigen (HBsAg) and anti-HBs was determined by a sensitive double-antibody radio-immunoassay technique in a series of patients with chronic liver diseases. HBsAg was demonstrated in 37 out of 98 consecutive patients with chronic hepatitis (38%) and in 14 out of 108 patients with non-alcoholic cirrhosis (13%). HBsAg was not found in any of the patients with steatosis, alcoholic cirrhosis, or primary biliary cirrhosis. In the patients with chronic hepatitis HbsAg or anti-HBs was demonstrated in 83% of the patients below 40 years of age in contrast to 48% of the patients more than 40 years of age. It is concluded that a substantial part of the patients with chronic hepatitis has serological evidence of actual or past hepatitis B virus infection. This is in contrast to the groups of patients with other chronic liver diseases.Keywords
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