The interaction of transcription factors with nucleosomal DNA
- 1 September 1992
- Vol. 14 (9), 597-603
- https://doi.org/10.1002/bies.950140905
Abstract
Nucleosome positioning is proposed to have an essential role in facilitating the regulated transcription of eukaryotic genes. Some transcription factors can bind to DNA when it is appropriately wrapped around the histone core, others cannot bind due to the severe deformation of DNA structure. The staged assembly of nucleosomes and positioning of histone‐DNA contacts away from promoter elements can facilitate the access of transcription factors to DNA. Positioned nucleosomes can also facilitate transcription through providing the appropriate scaffolding to bring regulatory factors bound at dispersed sites into juxtaposition.Keywords
This publication has 52 references indexed in Scilit:
- Structure of the TFIIIA-5 S DNA complexJournal of Molecular Biology, 1992
- Effects of DNA sequence and histone-histone interactions on nucleosome placementJournal of Molecular Biology, 1990
- Nucleosome positioning modulates accessibility of regulatory proteins to the mouse mammary tumor virus promoterCell, 1990
- Electrostatic mechanism of chromatin foldingJournal of Molecular Biology, 1990
- Photofootprint of nucleosome core DNA in intact chromatin having different structural statesJournal of Molecular Biology, 1988
- Statistical positioning of nucleosomes by specific protein-binding to an upstream activating sequence in yeastJournal of Molecular Biology, 1988
- Mapping of the sites of protection on a 5 S RNA gene by the Xenopus transcription factor IIIAJournal of Molecular Biology, 1986
- Sequence periodicities in chicken nucleosome core DNAJournal of Molecular Biology, 1986
- DNA bending and its relation to nucleosome positioningJournal of Molecular Biology, 1985
- Structure of the chromatosome, a chromatin particle containing 160 base pairs of DNA and all the histonesBiochemistry, 1978