Stimulation of immunoreactive somatostatin release from hypothalamic synaptosomes by high (K+) and dopamine.

Abstract

Effects of high (K+) [K+ concentrtion] and dopamine on release of immunoreactive somatostatin from isolated hypothalamic synaptosomes were studied in rats. High (K+) (60 mM) and dopamine (10-6 M) in the incubation media stimulated release of immunoreactive somatostatin, and the former effect was completely abolished by removal of Ca2+ from the media. Apparently hypothalamic somatostatinergic synaptosomes preserved at least 1 of the important basic properties of secretory cells.