Isolation and Characterization of Two Major Urinary Metabolites of Δ 1 -Tetrahydrocannabinol

Abstract
Two of the major metabolites which appear in rabbit urine after the administration of Δ1-tetrahydrocannabinol have been isolated and their structures have been tentatively established. The available evidence indicates that they are 7-carboxy-Δ1-tetrahydrocannabinols with an additional hydroxyl group on the side chain. The substances occur both free and as conjugates.