Resistance of Respiratory Ciliated Epithelium to Action of Polio and Adeno Viruses in vitro.

Abstract

Fragments of human adult or embryonic bronchial mucosa and of monkey trachea cultivated in vitro in heterologous media maintain during several weeks their morphological and functional differentiation. High concentrations of poliovirus or of adenovirus which rapidly destroyed the dedifferentiated growth of monkey kidney and HeLa strain cells in parallel or in mixed cultures had little or no destructive action on the differentiated respiratory epithelium and did not impair its ciliary activity.