Single oral dose of cefaclor for the treatment of infections with penicillinase-producing strains of Neisseria gonorrhoeae.

Abstract

A single oral dose of 3 g cefaclor was effective in the treatment of uncomplicated gonococcal infection in women due to penicillinase-producing strains of N. gonorrhoeae (PPNG). Cefaclor was equally active in vitro against both PPNG (MIC [minimal inhibitory concentration] range, 0.01-1.0 .mu.g/ml) and non-PPNG strains (MIC range, 0.005-2.0 .mu.g/ml). As empirical treatment cefaclor was effective in 53 of 57 (93%) patients compared with ampicillin, to which only 37 of 53 (69.8%) patients responded. This difference was attributed to the 40% incidence of PPNG in the patients studied; as expected, such patients responded poorly to ampicillin.