Comparative studies ontat mutants of three primate lentiviruses
- 1 September 1990
- journal article
- research article
- Published by Springer Nature in Archiv für die gesamte Virusforschung
- Vol. 114 (3-4), 243-250
- https://doi.org/10.1007/bf01310753
Abstract
A frame-shifttat gene mutant of human immunodeficiency virus type 1 (HIV-1), which showed no detectable trans-activation potential, was constructed in vitro. Upon transfection, this clone directed the synthesis of virus mRNAs,gag proteins and virion-associated reverse transcriptase (RT) at a low level as was observed with thetat mutants of HIV-2 and simian immunodeficiency virus isolated from African green monkey (SIVAGM). Using these mutant viruses, trans-activation efficiency of viral gene expression bytat was compared among HIV-1, HIV-2, and SIVAGM. SIVAGM seemed to be less dependent ontat for RT production than HIV-1 and HIV-2.Keywords
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