Hippocampal kindling and effects of antiepileptic drugs.

Abstract

The kindling effect of the hippocampus was investigated in rats. The development of behavioral manifestations in hippocampal kindling was similar to that seen in the case of amygdaloid kindling, but many more stimulations were required to evoke behavioral convulsions in the former. The tranfer phenomenon from amygdala to hippocampus was evident. There were no differences in effects of drugs [diazepam, chlorpromazine, amitriptyline, phenobarbital and phenytoin] on the seizure-discharge and the behavioral convulsions between the amygdaloid and the hippocampal kindled rats. The amygdala evidently plays an important role in the formation of hippocampal kindling, especially in the manifestation of behavioral changes. The hippocampal kindled rat, as well as amygdaloid kindled rat, is a useful animal model for evaluating the antiepileptic effect of various drugs.