Genetic Mapping of Ir Locus in Man: Linkage to Second Locus of HL-A

21 June 1974

journal article
Published by American Association for the Advancement of Science (AAAS) in Science

Vol. 184 (4143), 1301-1303
https://doi.org/10.1126/science.184.4143.1301

Abstract

Fifty-seven members of a family that spanned three generations were studied for antigen E and ragweed skin sensitivity and HL-A antigens. There was significant association between the haplotype HL-A 2-12 and antigen E skin hypersensitivity (F = .22 to .26) in this family. The map order is first locus of HL-A, second locus of HL-A, and IrE. These determinants are considered to be part of the linkage group HL-1.

Keywords

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