Validation of doubly labeled water for measuring energy expenditure during parenteral nutrition
Open Access
- 1 August 1986
- journal article
- research article
- Published by Elsevier in The American Journal of Clinical Nutrition
- Vol. 44 (2), 291-298
- https://doi.org/10.1093/ajcn/44.2.291
Abstract
The doubly labeled water method was compared with intake-balance for measuring energy expenditure in five patients receiving total parenteral nutrition (TPN). Because parenteral solutions were isotopically different from local water, patients had to be placed on TPN at least 10 days before the metabolic period. Approximately 0.1 g 2H2O and 0.25 g H218O per kg total body water were given orally. We collected saliva before, 3 h, and 4 h after the dose for measurement of total body water and urine before, 1 day, and 14 days after the dose for measurement of isotope eliminations. On day 14, total body weight was remeasured and change in body energy stores was calculated, assuming constant hydration. Intake was assessed from weights of TPN fluids plus dietary record for any oral intake. Energy expenditure from doubly labeled water (±SD) averaged 3 ± 6% greater than intake-balance. Doubly labeled water method is a noninvasive, nonrestrictive method for measuring energy expenditure in patients receiving TPN.This publication has 14 references indexed in Scilit:
- Isotope method for the measurement of carbon dioxide production rate in manThe American Journal of Clinical Nutrition, 1985
- Measurement of Energy Expenditure Using Doubly Labelled WaterInternational Journal of Sports Medicine, 1984
- Five-day comparison of the doubly labeled water method with respiratory gas exchangeThe American Journal of Clinical Nutrition, 1984
- Measurement of energy expenditure in humans by doubly labeled water methodJournal of Applied Physiology, 1982
- A new method for the rapid measurement of body composition in critically ill surgical patientsBritish Journal of Surgery, 1978
- Standards for stable isotope measurements in natural compoundsNature, 1978
- Fatty acid synthesis by the liver perfused with deuterated and tritiated waterBiochemistry, 1973
- Variation in Total Body Water with Muscle Glycogen Changes in ManActa Physiologica Scandinavica, 1970
- Theory of use of the turnover rates of body water for measuring energy and material balanceJournal of Theoretical Biology, 1966
- STUDIES OF TOTAL BODY WATER WITH TRITIUM 12JCI Insight, 1952