Purmorphamine activates the Hedgehog pathway by targeting Smoothened
- 20 November 2005
- journal article
- research article
- Published by Springer Nature in Nature Chemical Biology
- Vol. 2 (1), 29-30
- https://doi.org/10.1038/nchembio753
Abstract
Hedgehog (Hh) signaling is an important regulator of embryonic patterning, tissue regeneration, stem cell renewal and cancer growth. A purine derivative named purmorphamine was previously found to activate the Hh pathway and affect osteoblast differentiation through an unknown mechanism. We demonstrate here that purmorphamine directly targets Smoothened, a critical component of the Hh signaling pathway.Keywords
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