Control and detection of chemical reactions in microfluidic systems
Top Cited Papers
- 26 July 2006
- journal article
- review article
- Published by Springer Nature in Nature
- Vol. 442 (7101), 394-402
- https://doi.org/10.1038/nature05062
Abstract
Recent years have seen considerable progress in the development of microfabricated systems for use in the chemical and biological sciences. Much development has been driven by a need to perform rapid measurements on small sample volumes. However, at a more primary level, interest in miniaturized analytical systems has been stimulated by the fact that physical processes can be more easily controlled and harnessed when instrumental dimensions are reduced to the micrometre scale. Such systems define new operational paradigms and provide predictions about how molecular synthesis might be revolutionized in the fields of high-throughput synthesis and chemical production.Keywords
This publication has 93 references indexed in Scilit:
- Micromixers—a reviewJournal of Micromechanics and Microengineering, 2004
- Introduction: mixing in microfluidicsPhilosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2004
- Topologic mixing on a microfluidic chipApplied Physics Letters, 2004
- Neutrophil chemotaxis in linear and complex gradients of interleukin-8 formed in a microfabricated deviceNature Biotechnology, 2002
- Passive mixing in a three-dimensional serpentine microchannelJournal of Microelectromechanical Systems, 2000
- A Continuous-Flow Capillary Mixing Method to Monitor Reactions on the Microsecond Time ScaleBiophysical Journal, 1998
- Hydrodynamic Focusing on a Silicon Chip: Mixing Nanoliters in MicrosecondsPhysical Review Letters, 1998
- Mixing, Chaotic Advection, and TurbulenceAnnual Review of Fluid Mechanics, 1990
- The Mixing of FluidsScientific American, 1989
- Specific Enzymatic Amplification of DNA In Vitro: The Polymerase Chain ReactionCold Spring Harbor Symposia on Quantitative Biology, 1986