Platelet Functions in Relation to Dietary Fats in Farmers from two Regions of France

Abstract

To determine whether the long-term feeding of dietary fats affect platelet functions in man, platelet aggregation (to thrombin ADP, collagen, epinephrine) and clotting activity of platelet-rich plasma (PRP), platelet-poor plasma and of washed platelets, were studied in a mobile-laboratory in 44 healthy male farmers (40-45 years) from two French regions Var and Moselle, in relation to lipemia, glycemia, dietary nutriments, and platelet phospholipid composition. In the Moselle subjects, the platelet clotting activity of PRP and of washed platelets, the platelet aggregation to thrombin and ADP, were highly significantly (p * Presented in part at the IVth International Symposium on Atherosclerosis, August 1976, Tokyo, Japan and at the 50th meeting of the American Heart Association, November 1977, Miami, USA.