Papular acrodermatitis of childhood and other papulo-vesicular acro-located syndromes

Abstract

Papular acrodermatitis of childhood (PAC), first recognized in Milan and described by Gianotti in 1955, is an infectious disease of childhood, of low infectivity, fairly widespread, and characterized by non-relapsing erythemato-papular dermatitis localized to the face and limbs, lasting about 3 wk. Paracortical hyperplasia lymph nodes; acute hapatitis, usually anicteric, which lasts at least 2 mo. many progress to chronic liver disease; and hepatitis B surface antigenemia, subtype ayw, which may persist for a long time. PAC must be differentiated from other frequent papular or papulo-vesicular acro-located eruptions of unknown origin, which should be classified as papulo-vesicular acro-located syndrome until their etiology is clarified.