IPROVERATRIL - EXPERIMENTAL DATA ON CORONARY DILATATION + ANTIARRHYTHMIC ACTION

Abstract

Various cardiovascular effects of a new synthetic coronary vasodilator, [alpha]-isopropyl-[alpha] [(N-methyl-N-homoveratryl)-gamma-amino-propyl]-3, 4-dimethoxyphenylacetonitrile HC1 (D365, Iproveratril or Isoptin) were studied. In isolated perfused rabbit hearts the drug exerts a potent coronary vasodilator action, but can depress myocardial contractions and A-V conduction. In anesthetized cats it produces varying degrees of hypotension with bradycardia, and antagonizes ST-T changes induced by ouabain. It can also protect against CH Cl3-epinephrine and ouabain ventricular fibrillation. On isolated papillary muscle preparations it can lead to adrenergic blockade. It is concluded that in addition to its coronary dilator action, the drug exerts "quinidine-like" antiarrythmic effects, and appears to deserve further study.