In Vitro Fertilization with Low-Dose Clomiphene Citrate Stimulation in Women Who Respond Poorly to Superovulation
- 1 January 1997
- journal article
- Published by Springer Nature in Journal of Assisted Reproduction and Genetics
- Vol. 14 (9), 503-507
- https://doi.org/10.1023/a:1021171225322
Abstract
Purpose: Our experience with IVF using low-dose clomiphene citrate for stimulation in “non-” and “poor” responders was reviewed and the treatment outcomes with the previous controlled ovarian stimulation cycles in which hMG and GnRH agonist were used were compared. Methods: The treatment outcome in 11 non- and 20 poor responders having 30 and 53 clomiphene citrate IVF treatment cycles, respectively, were compared with the treatment outcome in the previous long-protocol buserelin/hMG cycles. Results: The clinical pregnancy rates per oocyte collection achieved in the first clomiphene citrate cycle in non (9.1%)- and poor (10%) responders were comparable to those achieved by poor responders (11.9%) who had buserelin/hMG using the long protocol. Although the numbers were small, a similar pregnancy rate could still be achieved in poor responders up to the third attempt using clomiphene citrate. Conclusions: IVF using long-protocol buserelin/hMG is more successful than using clomiphene citrate stimulation. However, this advantage may not be significant in those women with a previous poor response to buserelin/hMG. It is suggested that for such poor responders, three attempts of IVF in a clomiphene citrate cycle may offer a viable therapeutic alternative before reverting to more stressful, expensive, and time-consuming treatment.Keywords
This publication has 19 references indexed in Scilit:
- Poor responders to ovarian hyperstimulation may benefit from an attempt at natural-cycle oocyte retrievalJournal of Assisted Reproduction and Genetics, 1997
- Short Protocol of Gonadotropin Releasing Hormone Agonist Administration Gave Better Results in Long Protocol Poor‐Responders in IVF‐ETJournal of Obstetrics and Gynaecology Research, 1996
- Adjuvant growth hormone therapy in poor responders to in-vitro fertilization: a prospective randomized placebo-controlled double-blind studyHuman Reproduction, 1995
- Assisted hatching in the treatment of poor prognosis in vitro fertilization candidatesFertility and Sterility, 1994
- The poor-responder patient in an in vitro fertilization-embryo transfer programJournal of Assisted Reproduction and Genetics, 1993
- The prognostic importance of the number of oocytes retrieved and estradiol levels in poor and normal responders in in vitro fertilization (IVF) treatmentJournal of Assisted Reproduction and Genetics, 1992
- Poor oocyte quality rather than implantation failure as a cause of age-related decline in female fertilityThe Lancet, 1991
- The use of biosynthetic human growth hormone to augment ovulation induction with buserelin acetate/human menopausal gonadotropin in women with a poor ovarian responseFertility and Sterility, 1991
- Combined Treatment With Gonadotrophin Releasing Hormone Agonist and Gonadotrophins In Poor Responders To Hyperstimulation For In Vitro Fertilization (IVF): Clinical and Endocrine ResultsAustralian and New Zealand Journal of Obstetrics and Gynaecology, 1989
- Ultrasound Control of Clomiphene/Human Chorionic Gonadotropin Stimulated Cycles for Oocyte Recovery and in Vitro FertilizationFertility and Sterility, 1981