Solid Phase Peptide Synthesis by Oxidation-Reduction Condensation. Synthesis of LH–RH by Fragment Condensation on Solid Support
- 1 October 1973
- journal article
- research article
- Published by Oxford University Press (OUP) in Bulletin of the Chemical Society of Japan
- Vol. 46 (10), 3240-3247
- https://doi.org/10.1246/bcsj.46.3240
Abstract
Solid phase peptide synthesis by oxidation-reduction condensation was investigated. The fragment condensation on solid support was examined by employing two types of chain elongation, that from C-terminal amino acid to N-terminal amino acid (A type elongation) and that from N-terminal amino acid to C-terminal amino acid (B type elongation). The feasibility of these two approaches A and B was demonstrated in two syntheses of LH–RH (luteinizing hormone-releasing hormone). The LH–RH prepared from the two different chain elongations showed identical mobilities on tlc, exhibiting full activities of natural LH–RH (AVS 77-33 # 215-269).Keywords
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