Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis
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- 16 December 2007
- journal article
- research article
- Published by Springer Nature in Nature Genetics
- Vol. 40 (1), 29-31
- https://doi.org/10.1038/ng.2007.52
Abstract
We identified a SNP in the DPP6 gene that is consistently strongly associated with susceptibility to amyotrophic lateral sclerosis (ALS) in different populations of European ancestry, with an overall P value of 5.04 × 10−8 in 1,767 cases and 1,916 healthy controls and with an odds ratio of 1.30 (95% confidence interval (CI) of 1.18–1.43). Our finding is the first report of a genome-wide significant association with sporadic ALS and may be a target for future functional studies.Keywords
This publication has 15 references indexed in Scilit:
- Leveraging the HapMap Correlation Structure in Association StudiesAmerican Journal of Human Genetics, 2007
- Paraoxonase cluster polymorphisms are associated with sporadic ALSNeurology, 2006
- Molecular biology of amyotrophic lateral sclerosis: insights from geneticsNature Reviews Neuroscience, 2006
- ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosisNature Genetics, 2006
- Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studiesNature Genetics, 2006
- SMN genotypes producing less SMN protein increase susceptibility to and severity of sporadic ALSNeurology, 2005
- Accelerated Evolution of Nervous System Genes in the Origin of Homo sapiensCell, 2004
- VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic deathNature Genetics, 2003
- Amyotrophic Lateral SclerosisNew England Journal of Medicine, 2001
- British motor neuron disease twin study.Journal of Neurology, Neurosurgery & Psychiatry, 1997