Use of 125I-Fibrinogen Kinetic Data to Detect Disseminated Intravascular Coagulation and Deposition of Fibrin in Patients with Metastatic Cancer

Abstract

A technique using computerized data handling for following the fate of ¹²⁵I-fibrinogen through various physiological compartments is presented. Its use in detecting fibrin build up in patients with metastatic tumors and cancer-caused DIC is explained. An increase in j_3u (fractional catabolic rate as seen in the urine data) throughout the course of a study was found to be an important indicator of extravascular fibrin build up.