FREE IMMUNOGLOBULIN LIGHT CHAIN SYNTHESIS BY LYMPHOCYTES FROM PATIENTS WITH HYPOGAMMAGLOBULINEMIA
- 1 January 1978
- journal article
- research article
- Vol. 34 (2), 288-294
Abstract
Lymphocytes from 6 individuals with reduced or deficient serum immunoglobulins [Ig] of 1 or more class were assessed for Ig production in vitro. There was no clinical evidence of a secondary cause for hypogammaglobulinemia and 3 of the cases were receiving Ig therapy. The predominant Ig product in the culture supernatants from 4 cases was free L chain. Peripheral lymphocytes from 2 cases with partial IgA deficiency and from normal individuals exhibited a balanced synthesis of H and L chains. These findings are discussed with particular reference to free L chain synthesis by immature neoplastic B [bone marrow-derived] lymphocytes and to normal B lymphocyte differentiation.This publication has 22 references indexed in Scilit:
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